Eriomin: What a Lemon Flavonoid Brings to an Antioxidant Formula

Lemons are familiar, but the flavonoid we use in ZephyrCore is a concentrate, not a squeeze of juice. Eriomin® is a clinically studied lemon fruit extract (Citrus limon) standardized to at least 70% eriocitrin, which makes it a far richer source of this antioxidant than lemon alone could provide. ZephyrCore contains 200 mg per serving.*

This post covers what Eriomin® is, what the human research actually measured, and where we are careful about the boundaries.

A different flavonoid family

Eriocitrin is a citrus flavanone. That matters in a formula because many routines already include other flavonoids, such as curcumin and other polyphenols. A citrus flavanone belongs to a different flavonoid family, so it broadens antioxidant support rather than repeating what is already there.*

Inside ZephyrCore it plays the third role in a cascade. Setria® glutathione supplies the body's master antioxidant, R-lipoic acid helps regenerate spent antioxidants, and Eriomin® reinforces the system with a distinct kind of antioxidant support and help for a healthy inflammatory response.* We describe this as a mechanism of antioxidant support, consistent with the higher antioxidant capacity and lower lipid peroxidation seen in the research, and not as an outcome measured in the finished product.

What the human research measured

The main human study behind Eriomin® is a 12-week, randomized, double-blind, placebo-controlled trial of 103 adults published in Phytotherapy Research in 2019. Participants took 200, 400, or 800 mg a day. Among the markers measured were:

• Total antioxidant capacity, which rose by about 6%.
• Lipid peroxidation, a marker of oxidative stress, which fell by about 17%.
• Markers of inflammatory response, including hsCRP (down about 12%), IL-6 (down about 13%), and TNF-alpha (down about 11%).

These are the findings that support our language that Eriomin® provides antioxidant support and helps support a healthy inflammatory response.* A second, crossover-design trial published in the Journal of Medicinal Food in 2022 used 200 mg a day and corroborated the inflammatory-response findings.

The 200 mg dose in ZephyrCore matches a dose used in these studies.

Where we stay careful

Good science writing includes the caveats, so here are ours.

• The studied population. The Eriomin® trials enrolled adults with blood sugar above the normal range, and glucose was the primary endpoint. Our materials describe the antioxidant and inflammatory-response findings and do not present a blood sugar benefit for ZephyrCore. Where we mention glucose at all, we frame it as supporting healthy glucose metabolism within the normal range.*
• Ingredient, not finished product. "Clinically studied" refers to Eriomin® at the doses studied in published human research. The finished ZephyrCore formula has not itself been clinically tested.
• Dose. The 200 mg in ZephyrCore matches a dose used in the human research. We do not extend the findings to higher or lower amounts, and we do not describe results from the 400 and 800 mg arms as ZephyrCore results.

How it fits with the rest of a routine

Our education pages also note that Eriomin® is made from lemon, yet it supplies far more eriocitrin than the fruit alone could, which is the point of a standardized concentrate: a consistent, disclosed amount you can compare against the research.

ZephyrCore carries 0 mcg of iodine and no herbs, so Eriomin® arrives without anything that overlaps our sea-mineral or botanical formulas. It is designed to slot in beside vitamin C, vitamin E, CoQ10, curcumin, a multivitamin, or whatever your practitioner recommends. If a routine already includes a lemon flavonoid or another product with the same ingredients, talk with your practitioner about whether you need both.

A note on blood sugar

Lemon flavonoids and alpha-lipoic acid may affect blood sugar. If you take medication for blood sugar or diabetes, monitor closely and consult your healthcare provider before using ZephyrCore. It is for adults 18 and older, and it is not for use during pregnancy or breastfeeding. If you take any medication or have a medical condition, check with your provider first. Take 2 capsules daily with food, or as directed by your healthcare practitioner.

The short version

Eriomin® is a standardized lemon flavonoid with human research on antioxidant capacity and inflammatory-response markers at 200 mg a day. We include it because it adds a different kind of antioxidant support to glutathione and R-lipoic acid, and we tell you where the evidence stops.*

Sources

1. Ribeiro CB, et al. Effectiveness of Eriomin® in managing hyperglycemia and reversal of prediabetes condition: a double-blind, randomized, controlled study. Phytother Res. 2019;33(7):1921-1933. https://pubmed.ncbi.nlm.nih.gov/31183921/
2. Cesar TB, et al. Nutraceutical eriocitrin (Eriomin) reduces hyperglycemia by increasing glucagon-like peptide 1 and downregulates systemic inflammation: a crossover-randomized clinical trial. J Med Food. 2022;25(11):1050-1058. https://pubmed.ncbi.nlm.nih.gov/35796695/
3. Ramos FMM, et al. Lemon flavonoids nutraceutical (Eriomin®) attenuates prediabetes intestinal dysbiosis: a double-blind randomized controlled trial. Food Sci Nutr. 2023;11(11):7283-7295. https://pubmed.ncbi.nlm.nih.gov/37970408/
4. Yao L, et al. Eriocitrin: a review of pharmacological effects. Biomed Pharmacother. 2022;154:113563. https://pubmed.ncbi.nlm.nih.gov/35987162/
5. Linus Pauling Institute, Oregon State University. Flavonoids. Micronutrient Information Center. https://lpi.oregonstate.edu/mic/dietary-factors/phytochemicals/flavonoids

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.